what are protein interaction works and how are they useful?
Proteins interact with other proteins within cells in order to carry out important functions. These interactions help our cells carry out important tasks like signaling and gene regulation. When looking at these protein-protein interactions, we can create a map (network) of these different interactions and connect different proteins to important functions in the body. [1] Constructing these networks is important to be able to look at the organization and function of different systems as well as can be used to study different cellular processes/mechanisms.
discussion
Looking at these protein networks side-by-side, you can see that the proteins that interact with each other in each organism are very similar. Comparing the proteins involved in tyrosine catabolism specifically, essentially the same interactions occur. This is a good sign of homology and aids in choosing a model organism, as studying proteins that are involved with FAH in dario rerio can be useful in finding cures for diseases like Tyrosinemia Type 1 in humans.
references
[1]De Las Rivas, J., & Fontanillo, C. (2010). Protein–Protein interactions ESSENTIALS: Key concepts to building and analyzing Interactome NETWORKS. PLoS Computational Biology, 6(6). doi:10.1371/journal.pcbi.1000807
[2]Welcome to string. (n.d.). Retrieved May 08, 2021, from https://string-db.org/cgi/input?sessionId=bmGxqcog8pOP&input_page_show_search=on
[2]Welcome to string. (n.d.). Retrieved May 08, 2021, from https://string-db.org/cgi/input?sessionId=bmGxqcog8pOP&input_page_show_search=on
This web page was produced as an assignment for Genetics 564, a capstone course at UW- Madison.