Gene ontology of fah GENE
what is gene ontology?
Gene ontology is a way to describe genes through a bioinformatic approach. It combines multiple aspects of a gene to create an overall picture of what the gene does, looking at molecular function, biological process, and cellular component. These different aspects, when looked at together, work to show the overall function of a gene and it's representation across species. Overall, gene ontology helps to classify a gene using many different aspects to get a well-rounded idea of a genes function.
FAH RESULTS
[1]
BIOLOGICAL PROCESS
DISCUSSION
The GO terms used for the FAH gene collectively are catalytic activity, tyrosine catabolism, and extracellular exosomes. Looking at this three terms as a whole, it can be determined that the function of the FAH gene is very important in the pathway of tyrosine breakdown and does so by catalyzing a hydrolysis reaction that is involved in the formation/release of extracellular exosomes in the cell. The overall importance of the gene in the breakdown of tyrosine is highlighted within these terms, as well as the mechanisms it takes to go about doing this.
references
[1] Thomas PD, Ebert D, Muruganujan A, Mushayahama T, Albou LP, Mi H. PANTHER: Making genome-scale phylogenetics accessible to all. Protein Sci. 2022 Jan;31(1):8-22. DOI:10.1002/pro.4218 [abstract | full text]
[2] Cooper GM. The Cell: A Molecular Approach. 2nd edition. Sunderland (MA): Sinauer Associates; 2000. The Central Role of Enzymes as Biological Catalysts. Available from: https://www.ncbi.nlm.nih.gov/books/NBK9921/
[3] Doyle, L. M., & Wang, M. Z. (2019). Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis. Cells, 8(7), 727. https://doi.org/10.3390/cells8070727
[2] Cooper GM. The Cell: A Molecular Approach. 2nd edition. Sunderland (MA): Sinauer Associates; 2000. The Central Role of Enzymes as Biological Catalysts. Available from: https://www.ncbi.nlm.nih.gov/books/NBK9921/
[3] Doyle, L. M., & Wang, M. Z. (2019). Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis. Cells, 8(7), 727. https://doi.org/10.3390/cells8070727
This web page was produced as an assignment for Genetics 564, a capstone course at UW- Madison.